Double-strand breaks and tumorigenesis.
نویسندگان
چکیده
The establishment of connections between biochemical defects and clinical disease is a major goal of modern molecular genetics. In this review, we examine the current literature that relates defects in the two major DNA double-strand-break repair pathways--homologous recombination and nonhomologous end-joining--with the development of human tumors. Although definitive proof has yet to be obtained, the current literature is highly suggestive of such a link.
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عنوان ژورنال:
- Trends in cell biology
دوره 11 11 شماره
صفحات -
تاریخ انتشار 2001